Williams, Long, Ducoste, and Tuck Receive Award for Interdisciplinary Research in Plant Systems Biology By the National Science Foundation

Dr. Cranos Williams

Drs. Cranos Williams (PI), Terri Long (CoPI), James Tuck (CoPI), and Joel Ducoste (CoPI) have been awarded $999,754 by the National Science Foundation for research on Dynamic Regulatory Modeling of the Iron Deficiency Response in Arabidopsis thaliana.

The award will run from August 15th, 2012 to July 31st, 2017.

Research Abstract

Multicellular organisms such as plants react to abiotic stress with a multitude of physiological and molecular responses orchestrated by key regulatory proteins, or transcription factors. Experimental datasets, such as transcriptional profiles, are often used to identify critical, yet, uncharacterized transcription factors in these responses.  Limitations in these datasets caused by constraints in experimental perturbations and finite experimental resources are the reasons why traditional approaches have revealed few key regulating and controlling elements, particularly in model organisms such as Arabidopsis thaliana.  The PIs hypothesize that additional computer-based simulations from dynamic gene regulatory models can be used in combination with clustering approaches to expand the perturbation space and assess secondary and tertiary control mechanisms, leading to the identification of hidden regulatory relationships between genes and transcription factors. They propose to develop a novel modeling and parallel computing paradigm to identify previously uncharacterized regulatory components that control iron homeostasis in A. thaliana across multiple cell types.

The interdisciplinary approach proposed by these PIs presents a new paradigm that 1) unifies novel genomic experimental techniques, engineering modeling approaches, and parallel computing to clarify the role of known regulatory elements and 2) identifies new regulating components involved in iron homeostasis within and across different cell types. Their integration of systems engineering, plant biology, and computer engineering will help create new solutions to existing problems and encourages a vision for addressing challenging issues that have, to date, remained intimidating using traditional approaches. Their results will lead to methods for stretching critical resources and increasing crop yields to feed the projected 9 billion people in 2050 through development of plants that exhibit improved function in low nutrient soils, or plants that can contain elevated nutrient content.

View the original article here